Oncotarget recently published "ETAF15 contributes to the radiation-inducible stress response in cancer" which reported that genetically silenced TAF15 which led to a significant reduction in proliferation of NSCLC cells.
Cells depleted of TAF15 exhibited cell cycle arrest and enhanced apoptosis through activation and accumulation of p53. In combination with radiation, TAF15 knockdown led to a significant reduction in the surviving fraction of NSCLC cell lines.
To determine the importance of TAF15 surface expression, they targeted TAF15 with an antibody.
In combination with radiation, the anti-TAF15 antibody led to a reduction in the surviving fraction of cancer cells.
These Oncotarget studies show that TAF15 is a radiation-inducible molecular target that is accessible to anti-cancer antibodies and enhances cell viability in response to radiation.
These Oncotarget studies show that TAF15 is a radiation-inducible molecular target that is accessible to anti-cancer antibodies and enhances cell viability in response to radiation.
Dr. Dennis E. Hallahan from The Washington University in St. Louis said, "Resistance to therapy is a significant challenge during the treatment of non-small cell lung cancer (NSCLC)"
They identified TATA-box-binding protein-associated factor 15 as one protein that is expressed on the surface of NSCLC cells following irradiation.
Under normal conditions, TAF15 controls cellular viability through the regulation of cell cycle and cell death-related genes.
A previous study showed that human antibody PAT-BA4 that recognizes a variant of cell surface TAF15 inhibits cancer cell motility and cell adhesion in stomach cancer and melanoma.
In the present study, the Oncotarget authors found that IR enhanced the surface expression of TAF15 in NSCLC cell lines.
They studied the effect of anti-TAF15 antibody on cells with surface associated TAF15, and its impact on cell survival when combined with IR.
The Hallahan Research Team concluded in their Oncotarget Research Article that, TAF15 is a radiation-inducible molecular target for the development of anti-cancer antibodies.
Blocking TAF15 with an antibody is a feasible approach to enhance the cytotoxicity of radiation in NSCLC.
This targeting approach may lead to improved outcomes in NSCLC with enhanced expression of TAF15.
DOI - https://doi.org/10.18632/oncotarget.27663
Full text - https://www.oncotarget.com/article/27663/text/
Correspondence to - Dennis E. Hallahan - dhallahan@wustl.edu
Keywords - TAF15, radiation inducible, lung cancer, antibody
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