Abstract
Pierre-Jean Lamy1,2, Brigitte Trétarre3, Xavier Rebillard1, Marie Sanchez4, Sylvie Cénée4 and Florence Ménégaux4
1Service Urologie, Clinique Beau Soleil, Montpellier, France
2Institut d’Analyse Génomique-Imagenome, Labosud, Montpellier, France
3Registre des Tumeurs de l’Hérault, ICM, Montpellier, France
4Université Paris-Saclay, Université Paris-Sud, CESP (Center for Research in Epidemiology and Population Health), Inserm, Team Cancer and Environment, Villejuif, France
Correspondence to:
Pierre-Jean Lamy, email: pierre-jean.lamy@labosud-ocbiologie.fr
Keywords: family history of cancer; epidemiology; prostate cancer; breast cancer; Gleason score
Abbreviations: BCa: breast cancer; GS: Gleason score; OR: Odd ratio; PCa: prostate cancer
Received: March 01, 2018 Accepted: April 17, 2018 Published: May 04, 2018
ABSTRACT
Introduction: Familial aggregation is now well established with an increased risk of prostate cancer in patients with a family history of prostate cancer in first degree relatives. The aim of this paper was to investigate the role of family history of cancer in first degree relatives in prostate cancer risk.
Results: As expected, a family history of prostate cancer in first-degree relatives was more frequent in cases than in controls (OR 3.10, 95% CI 2.32–4.15). A family history of early BCa (before age 50) in first-degree relatives was more frequent in cases than in controls (OR 1.79, 95% CI 1.09–2.94) with higher risk of aggressive PCa. The association was more pronounced for BCa in daughters (OR 15.26 95% CI 1.95–120).
Conclusions: In summary, a family history of BCa in first degree relatives before age 50 may increases the risk of PCa with higher Gleason score. This finding could suggest a specific prostate surveillance and/or genetic counselling for men who present such familial history.
Methods: EPIdemiological study of Prostate CAncer (EPICAP) is a population-based case-control study specifically designed to investigate the role of environmental and genetic factors in prostate cancer. Detailed information on family history of cancer in first degree relatives (parents, brothers and sisters, children) was collected as well as the age of occurrence and the localization of each cancer. Overall, 819 cases and 879 controls have been included.
