Oncotarget

June 19, 2018

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About The Cover

The cover for issue 47 of Oncotarget features Figure 6, "MR-409 down-regulates IGF-1 expression in cancer cells," by Cui, et al.

Table of Contents

Letters to the Editor

Maintenance ramucirumab monotherapy after intolerable toxicities following docetaxel plus ramucirumab

Maintenance ramucirumab monotherapy after intolerable toxicities following docetaxel plus ramucirumab

https://doi.org/10.18632/oncotarget.25623

Akito Hata,  and Nobuyuki Katakami
28292-28293
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Research Papers: Immunology

BRAF inhibitors stimulate inflammasome activation and interleukin 1 beta production in dendritic cells

BRAF inhibitors stimulate inflammasome activation and interleukin 1 beta production in dendritic cells

https://doi.org/10.18632/oncotarget.25511

Eva Hajek, Franziska Krebs, Rebekka Bent, Katharina Haas, Antje Bast, Ivo Steinmetz, Andrea Tuettenberg, Stephan Grabbe,  and Matthias Bros
28294-28308

Research Papers

IL-23 enhances the malignant properties of hepatoma cells by attenuation of HNF4α

IL-23 enhances the malignant properties of hepatoma cells by attenuation of HNF4α

https://doi.org/10.18632/oncotarget.24875

Qing Jiang, Yuanli Sun, Zilong Guo, Ru Chen, Simin Ma, Mingpeng Fu, Huifen Zhu, Qin Ning, Ping Lei,  and Guanxin Shen
28309-28321
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Proteomics identification and characterization of MbovP730 as a potential DIVA antigen of Mycoplasma bovis

Proteomics identification and characterization of MbovP730 as a potential DIVA antigen of Mycoplasma bovis

https://doi.org/10.18632/oncotarget.22265

Farhan Anwar Khan, Gang Zhao, Yusi Guo, Muhammad Faisal, Jin Chao, Xi Chen, Chenfei He, Harish Menghwar, Rahim Dad, Muhammad Zubair, Changmin Hu, Yingyu Chen, Huanchun Chen, Zhang Rui,  and Aizhen Guo
28322-28336
Abstract  |  PDF  |  HTML  |  How to cite

The human blood DNA methylome identifies crucial role of β-catenin in the pathogenesis of Kawasaki disease

The human blood DNA methylome identifies crucial role of β-catenin in the pathogenesis of Kawasaki disease

https://doi.org/10.18632/oncotarget.25305

Kuang-Den Chen, Ying-Hsien Huang, Mindy Ming-Huey Guo, Tzu-Yang Lin, Wei-Teng Weng, Hsiang-Jen Yang, Kuender D. Yang,  and Ho-Chang Kuo
28337-28350
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  How to cite

Increased Nrf2 expression by renal cell carcinoma is associated with postoperative chronic kidney disease and an unfavorable prognosis

Increased Nrf2 expression by renal cell carcinoma is associated with postoperative chronic kidney disease and an unfavorable prognosis

https://doi.org/10.18632/oncotarget.25322

Hideo Yuki, Takao Kamai, Satoshi Murakami, Satoru Higashi, Takahiro Narimatsu, Tsunehito Kambara, Hironori Betsunoh, Hideyuki Abe, Kyoko Arai, Hiromichi Shirataki,  and Ken-Ichiro Yoshida
28351-28363
Abstract  |  PDF  |  HTML  |  How to cite

Tumor-derived granzyme B-expressing neutrophils acquire antitumor potential after lipid A treatment

Tumor-derived granzyme B-expressing neutrophils acquire antitumor potential after lipid A treatment

https://doi.org/10.18632/oncotarget.25342

Amandine Martin, Cédric Seignez, Cindy Racoeur, Nicolas Isambert, Nesrine Mabrouk, Alessandra Scagliarini, Sylvie Reveneau, Laurent Arnould, Ali Bettaieb, Jean-François Jeannin,  and Catherine Paul
28364-28378
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  How to cite

MicroRNA analysis of gastroenteropancreatic neuroendocrine tumors and metastases

MicroRNA analysis of gastroenteropancreatic neuroendocrine tumors and metastases

https://doi.org/10.18632/oncotarget.25357

Nadine Zimmermann, Juliana Knief, Tim Kacprowski, Pamela Lazar-Karsten, Tobias Keck, Franck Billmann, Sebastian Schmid, Kim Luley, Hendrik Lehnert, Georg Brabant,  and Christoph Thorns
28379-28390
Abstract  |  PDF  |  HTML  |  How to cite

MiR-199a-3p decreases esophageal cancer cell proliferation by targeting p21 activated kinase 4

MiR-199a-3p decreases esophageal cancer cell proliferation by targeting p21 activated kinase 4

https://doi.org/10.18632/oncotarget.25375

Pornima Phatak, Whitney M. Burrows, Ingrid E. Chesnick, Mohan E. Tulapurkar, Jaladanki N. Rao, Douglas J. Turner, Anne W. Hamburger, Jian-Ying Wang,  and James M. Donahue
28391-28407
Abstract  |  PDF  |  HTML  |  How to cite

Cancer-related transcription regulator protein NAC1 forms a protein complex with CARM1 for ovarian cancer progression

Cancer-related transcription regulator protein NAC1 forms a protein complex with CARM1 for ovarian cancer progression

https://doi.org/10.18632/oncotarget.25400

Naomi Nakayama, Gyosuke Sakashita, Yuko Nariai, Hiroaki Kato, Kaori Sinmyozu, Jun-Ichi Nakayama, Satoru Kyo, Takeshi Urano,  and Kentaro Nakayama
28408-28420
Abstract  |  PDF  |  HTML  |  How to cite

Comparative molecular characterization of typical and exceptional responders in glioblastoma

Comparative molecular characterization of typical and exceptional responders in glioblastoma

https://doi.org/10.18632/oncotarget.25420

Kristin Wipfler, Adam S. Cornish,  and Chittibabu Guda
28421-28433
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  How to cite

Deferasirox, an oral iron chelator, with gemcitabine synergistically inhibits pancreatic cancer cell growth in vitro and in vivo

Deferasirox, an oral iron chelator, with gemcitabine synergistically inhibits pancreatic cancer cell growth in vitro and in vivo

https://doi.org/10.18632/oncotarget.25421

Shuhei Shinoda, Seiji Kaino, Shogo Amano, Hirofumi Harima, Toshihiko Matsumoto, Koichi Fujisawa, Taro Takami, Naoki Yamamoto, Takahiro Yamasaki,  and Isao Sakaida
28434-28444
Abstract  |  PDF  |  HTML  |  How to cite

Silencing NIK potentiates anti-VEGF therapy in a novel 3D model of colorectal cancer angiogenesis

Silencing NIK potentiates anti-VEGF therapy in a novel 3D model of colorectal cancer angiogenesis

https://doi.org/10.18632/oncotarget.25442

Chrissta X. Maracle, Kim C.M. Jeucken, Boy Helder, Thomas M. van Gulik, Anne Steins, Hanneke W.M. van Laarhoven,  and Sander W. Tas
28445-28455
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  How to cite

Simultaneous delivery of olaparib and carboplatin in PEGylated liposomes imparts this drug combination hypersensitivity and selectivity for breast tumor cells

Simultaneous delivery of olaparib and carboplatin in PEGylated liposomes imparts this drug combination hypersensitivity and selectivity for breast tumor cells

https://doi.org/10.18632/oncotarget.25466

Vojtech Novohradsky, Juraj Zajac, Oldrich Vrana, Jana Kasparkova,  and Viktor Brabec
28456-28473
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  How to cite

Role of drug transporters in the sensitivity of acute myeloid leukemia to sorafenib

Role of drug transporters in the sensitivity of acute myeloid leukemia to sorafenib

https://doi.org/10.18632/oncotarget.25494

Rocio I.R. Macias, Anabel Sánchez-Martín, Gabriela Rodríguez-Macías, Luis I. Sánchez-Abarca, Elisa Lozano, Elisa Herraez, Maria D. Odero, José L. Díez- Martín, Jose J.G. Marin,  and Oscar Briz
28474-28485
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  How to cite

Efficacy of a new cancer treatment strategy based on eradication of tumor-initiating stem cells in a mouse model of Krebs-2 solid adenocarcinoma

Efficacy of a new cancer treatment strategy based on eradication of tumor-initiating stem cells in a mouse model of Krebs-2 solid adenocarcinoma

https://doi.org/10.18632/oncotarget.25503

Ekaterina A. Potter, Anastasia S. Proskurina, Genrikh S. Ritter, Evgenia V. Dolgova, Valeriy P. Nikolin, Nelly A. Popova, Oleg S. Taranov, Yaroslav R. Efremov, Sergey I. Bayborodin, Aleksandr A. Ostanin, Elena R. Chernykh, Nikolay A. Kolchanov,  and Sergey S. Bogachev
28486-28499
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  How to cite

A bi-specific inhibitor targeting IL-17A and MMP-9 reduces invasion and motility in MDA-MB-231 cells

A bi-specific inhibitor targeting IL-17A and MMP-9 reduces invasion and motility in MDA-MB-231 cells

https://doi.org/10.18632/oncotarget.25526

Dana Koslawsky, Marianna Zaretsky, Ron Alcalay, Ohad Mazor, Amir Aharoni,  and Niv Papo
28500-28513
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  How to cite

Mutations of p53 decrease sensitivity to the anthracycline treatments in bladder cancer cells

Mutations of p53 decrease sensitivity to the anthracycline treatments in bladder cancer cells

https://doi.org/10.18632/oncotarget.25530

Sony Pandey, Jennifer Bourn,  and Maria Cekanova
28514-28531
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  How to cite

Prostate cancer susceptibility gene HIST1H1A is a modulator of androgen receptor signaling and epithelial to mesenchymal transition

Prostate cancer susceptibility gene HIST1H1A is a modulator of androgen receptor signaling and epithelial to mesenchymal transition

https://doi.org/10.18632/oncotarget.25536

Kendra A. Williams, Minnkyong Lee, Jean M. Winter, Derek E. Gildea, Carla Calagua, Natasha L. Curry, Jens Lichtenberg, Huihui Ye,  and Nigel P.S. Crawford
28532-28546
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  How to cite

Targeting of BMI-1 expression by the novel small molecule PTC596 in mantle cell lymphoma

Targeting of BMI-1 expression by the novel small molecule PTC596 in mantle cell lymphoma

https://doi.org/10.18632/oncotarget.25558

Aya Maeda, Yuki Nishida, Marla Weetall, Liangxian Cao, Arthur Branstrom, Jo Ishizawa, Takenobu Nii, Wendy D. Schober, Yoshiaki Abe, Kosei Matsue, Mariko Yoshimura, Shinya Kimura,  and Kensuke Kojima
28547-28560
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  How to cite

Ipilimumab plus nivolumab and DNA-repair defects in AR-V7-expressing metastatic prostate cancer

Ipilimumab plus nivolumab and DNA-repair defects in AR-V7-expressing metastatic prostate cancer

https://doi.org/10.18632/oncotarget.25564

Karim Boudadi, Daniel L. Suzman, Valsamo Anagnostou, Wei Fu, Brandon Luber, Hao Wang, Noushin Niknafs, James R. White, John L. Silberstein, Rana Sullivan, Donna Dowling, Rana Harb, Thomas R. Nirschl, Brendan A. Veeneman, Scott A. Tomlins, Yipeng Wang, Adam Jendrisak, Ryon P. Graf, Ryan Dittamore, Michael A. Carducci, Mario A. Eisenberger, Michael C. Haffner, Alan K. Meeker, James R. Eshleman, Jun Luo, Victor E. Velculescu, Charles G. Drake,  and Emmanuel S. Antonarakis
28561-28571
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  How to cite

2′-deoxy-2′-[18F] fluoro-D-glucose positron emission tomography, diffusion-weighted magnetic resonance imaging, and choline spectroscopy to predict the activity of cetuximab in tumor xenografts derived from patients with squamous cell carcinoma of the head and neck

2′-deoxy-2′-[18F] fluoro-D-glucose positron emission tomography, diffusion-weighted magnetic resonance imaging, and choline spectroscopy to predict the activity of cetuximab in tumor xenografts derived from patients with squamous cell carcinoma of the head and neck

https://doi.org/10.18632/oncotarget.25574

Lionel Mignion, Sandra Schmitz, Nicolas Michoux, Xavier Caignet, Rose-Marie Goebbels, Anne Bol, Marie-Aline C. Neveu, Vincent Grégoire, Thierry Duprez, Renaud Lhommel, Fréderic Amant, Els Hermans, Benedicte F. Jordan,  and Jean-Pascal Machiels
28572-28585
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  How to cite

The histone deacetylase inhibitor panobinostat is a potent antitumor agent in canine diffuse large B-cell lymphoma

The histone deacetylase inhibitor panobinostat is a potent antitumor agent in canine diffuse large B-cell lymphoma

https://doi.org/10.18632/oncotarget.25580

Joana N.R. Dias, Sandra I. Aguiar, Diane M. Pereira, Ana S. André, Lurdes Gano, João D.G. Correia, Belmira Carrapiço, Barbara Rütgen, Rui Malhó, Conceição Peleteiro, João Goncalves, Cecília M.P. Rodrigues, Solange Gil, Luís Tavares,  and Frederico Aires-da-Silva
28586-28598
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  How to cite

Thymoquinone challenges UHRF1 to commit auto-ubiquitination: a key event for apoptosis induction in cancer cells

Thymoquinone challenges UHRF1 to commit auto-ubiquitination: a key event for apoptosis induction in cancer cells

https://doi.org/10.18632/oncotarget.25583

Abdulkhaleg Ibrahim, Mahmoud Alhosin, Christophe Papin, Khalid Ouararhni, Ziad Omran, Mazin A. Zamzami, Abdulrahman Labeed Al-Malki, Hani Choudhry, Yves Mély, Ali Hamiche, Marc Mousli,  and Christian Bronner
28599-28611
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  How to cite

P-Rex1 is dispensable for Erk activation and mitogenesis in breast cancer

P-Rex1 is dispensable for Erk activation and mitogenesis in breast cancer

https://doi.org/10.18632/oncotarget.25584

Laura Barrio-Real, Cynthia Lopez-Haber, Victoria Casado-Medrano, Alexander G. Goglia, Jared E. Toettcher, Maria J. Caloca,  and Marcelo G. Kazanietz
28612-28624
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  How to cite

RIOK1 kinase activity is required for cell survival irrespective of MTAP status

RIOK1 kinase activity is required for cell survival irrespective of MTAP status

https://doi.org/10.18632/oncotarget.25586

Alexandra Hörmann, Barbara Hopfgartner, Thomas Köcher, Maja Corcokovic, Teresa Krammer, Christoph Reiser, Gerd Bader, Junwei Shi, Katharina Ehrenhöfer, Simon Wöhrle, Norbert Schweifer, Christopher R. Vakoc, Norbert Kraut, Mark Pearson, Mark Petronczki,  and Ralph A. Neumüller
28625-28637
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  How to cite

Oral administration of fructose exacerbates liver fibrosis and hepatocarcinogenesis via increased intestinal permeability in a rat steatohepatitis model

Oral administration of fructose exacerbates liver fibrosis and hepatocarcinogenesis via increased intestinal permeability in a rat steatohepatitis model

https://doi.org/10.18632/oncotarget.25587

Kenichiro Seki, Mitsuteru Kitade, Norihisa Nishimura, Kosuke Kaji, Kiyoshi Asada, Tadashi Namisaki, Kei Moriya, Hideto Kawaratani, Yasushi Okura, Hiroaki Takaya, Yasuhiko Sawada, Shinya Sato, Keisuke Nakanishi,  and Hitoshi Yoshiji
28638-28651
Abstract  |  PDF  |  HTML  |  How to cite

Epithelial differentiation with microlumen formation in meningioma: diagnostic utility of NHERF1/EBP50 immunohistochemistry

Epithelial differentiation with microlumen formation in meningioma: diagnostic utility of NHERF1/EBP50 immunohistochemistry

https://doi.org/10.18632/oncotarget.25595

Maria-Magdalena Georgescu, Adriana Olar, Bret C. Mobley, Phyllis L. Faust,  and Jack M. Raisanen
28652-28665
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  How to cite

Role for the transcriptional activator ZRF1 in early metastatic events in breast cancer progression and endocrine resistance

Role for the transcriptional activator ZRF1 in early metastatic events in breast cancer progression and endocrine resistance

https://doi.org/10.18632/oncotarget.25596

Aysegül Kaymak, Sergi Sayols, Thaleia Papadopoulu,  and Holger Richly
28666-28690
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  How to cite

Advantage of HSP110 (T17) marker inclusion for microsatellite instability (MSI) detection in colorectal cancer patients

Advantage of HSP110 (T17) marker inclusion for microsatellite instability (MSI) detection in colorectal cancer patients

https://doi.org/10.18632/oncotarget.25611

Gustavo Noriz Berardinelli, Cristovam Scapulatempo-Neto, Ronílson Durães, Marco Antônio de Oliveira, Denise Guimarães,  and Rui Manuel Reis
28691-28701
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  How to cite

Lysis-independent potentiation of immune checkpoint blockade by oncolytic virus

Lysis-independent potentiation of immune checkpoint blockade by oncolytic virus

https://doi.org/10.18632/oncotarget.25614

Anton Oseledchyk, Jacob M. Ricca, Mathieu Gigoux, Brian Ko, Gil Redelman-Sidi, Tyler Walther, Cailian Liu, Gopa Iyer, Taha Merghoub, Jedd D. Wolchok,  and Dmitriy Zamarin
28702-28716
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  How to cite

Cancer-predicting transcriptomic and epigenetic signatures revealed for ulcerative colitis in patient-derived epithelial organoids

Cancer-predicting transcriptomic and epigenetic signatures revealed for ulcerative colitis in patient-derived epithelial organoids

https://doi.org/10.18632/oncotarget.25617

Samaneh K. Sarvestani, Steven A. Signs, Veronique Lefebvre, Stephen Mack, Ying Ni, Andrew Morton, Ernest R. Chan, Xiaoxia Li, Paul Fox, Angela Ting, Matthew F. Kalady, Michael Cruise, Jean Ashburn, Jennifer Stiene, Wei Lai, David Liska, Shao Xiang,  and Emina H. Huang
28717-28730
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  How to cite

Targeting Polo-like kinase 1 and TRAIL enhances apoptosis in non-small cell lung cancer

Targeting Polo-like kinase 1 and TRAIL enhances apoptosis in non-small cell lung cancer

https://doi.org/10.18632/oncotarget.25618

Alfiah Noor, Ijeoma Adaku Umelo, Peter Kronenberger, Philippe Giron, Elly De Vlieghere, Olivier De Wever, Erik Teugels,  and Jacques De Grève
28731-28744
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  How to cite

Growth hormone-releasing hormone (GHRH) and its agonists inhibit hepatic and tumoral secretion of IGF-1

Growth hormone-releasing hormone (GHRH) and its agonists inhibit hepatic and tumoral secretion of IGF-1

https://doi.org/10.18632/oncotarget.25676

Tengjiao Cui,  and Andrew V. Schally
28745-28756
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  How to cite  |  Press Release

Clinical Research Papers

Trends and outcomes of women with synchronous endometrial and ovarian cancer

Trends and outcomes of women with synchronous endometrial and ovarian cancer

https://doi.org/10.18632/oncotarget.25550

Koji Matsuo, Hiroko Machida, Erin A. Blake, Laura L. Holman, Bobbie J. Rimel, Lynda D. Roman,  and Jason D. Wright
28757-28771
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  How to cite

Chemical exchange saturation transfer MRI serves as predictor of early progression in glioblastoma patients

Chemical exchange saturation transfer MRI serves as predictor of early progression in glioblastoma patients

https://doi.org/10.18632/oncotarget.25594

Sebastian Regnery, Sebastian Adeberg, Constantin Dreher, Johanna Oberhollenzer, Jan-Eric Meissner, Steffen Goerke, Johannes Windschuh, Katerina Deike-Hofmann, Sebastian Bickelhaupt, Moritz Zaiss, Alexander Radbruch, Martin Bendszus, Wolfgang Wick, Andreas Unterberg, Stefan Rieken, Jürgen Debus, Peter Bachert, Mark Ladd, Heinz-Peter Schlemmer,  and Daniel Paech
28772-28783
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  How to cite

Induction chemotherapy reduces extracellular heat shock protein 72 levels, inflammation, lipoperoxidation and changes insulin sensitivity in children and adolescents newly diagnosed with acute lymphoblastic leukemia

Induction chemotherapy reduces extracellular heat shock protein 72 levels, inflammation, lipoperoxidation and changes insulin sensitivity in children and adolescents newly diagnosed with acute lymphoblastic leukemia

https://doi.org/10.18632/oncotarget.25609

Ana Paula Trussardi Fayh, Camila de Carvalho Gomes, Helena Trevisan Schroeder, Carlos Henrique de Lemos Muller, Telma Maria de Araújo Moura Lemos,  and Mauricio Krause
28784-28795
Abstract  |  PDF  |  HTML  |  How to cite

Corrections

Correction: Genipin suppresses colorectal cancer cells by inhibiting the Sonic Hedgehog pathway

Correction: Genipin suppresses colorectal cancer cells by inhibiting the Sonic Hedgehog pathway

https://doi.org/10.18632/oncotarget.25677

Bo Ram Kim, Yoon A. Jeong, Yoo Jin Na, Seong Hye Park, Min Jee Jo, Jung Lim Kim, Soyeon Jeong, Suk-Young Lee, Hong Jun Kim, Sang Cheul Oh,  and Dae-Hee Lee
28796-28796
Correction  |  PDF  |  How to cite

Correction: Targeting Hsp27/eIF4E interaction with phenazine compound: a promising alternative for castration-resistant prostate cancer treatment

Correction: Targeting Hsp27/eIF4E interaction with phenazine compound: a promising alternative for castration-resistant prostate cancer treatment

https://doi.org/10.18632/oncotarget.25683

Hajer Ziouziou, Claudia Andrieu, Erik Laurini, Sara Karaki, Maurizio Fermeglia, Ridha Oueslati, David Taieb, Michel Camplo, Olivier Siri, Sabrina Pricl, Maria Katsogiannou,  and Palma Rocchi
28797-28797
Correction  |  PDF  |  How to cite

Correction: Combining molecular and immunohistochemical analyses of key drivers in primary melanomas: interplay between germline and somatic variations

Correction: Combining molecular and immunohistochemical analyses of key drivers in primary melanomas: interplay between germline and somatic variations

https://doi.org/10.18632/oncotarget.25684

William Bruno, Claudia Martinuzzi, Bruna Dalmasso, Virginia Andreotti, Lorenza Pastorino, Francesco Cabiddu, Marina Gualco, Francesco Spagnolo, Alberto Ballestrero, Paola Queirolo, Federica Grillo, Luca Mastracci,  and Paola Ghiorzo
28798-28798
Correction  |  PDF  |  How to cite


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