Alzheimer disease research in the 21^st century: past and current failures, new perspectives and funding priorities

Environmental tobacco smoke increases autophagic effects but decreases longevity associated with Sirt-1 protein expression in young C57BL mice hearts

De novo HAPLN1 expression hallmarks Wnt-induced stem cell and fibrogenic networks leading to aggressive human hepatocellular carcinomas

FERMT2 rs17125944 polymorphism with Alzheimer’s disease risk: a replication and meta-analysis

Conditioned medium derived from rat amniotic epithelial cells confers protection against inflammation, cancer, and senescence

Endothelial SIRT1 prevents adverse arterial remodeling by facilitating HERC2-mediated degradation of acetylated LKB1

Run-on of germline apoptosis promotes gonad senescence in C. elegans

Estrogen receptor alpha inhibits senescence-like phenotype and facilitates transformation induced by oncogenic ras in human mammary epithelial cells

Careful neuropsychological testing reveals a novel genetic marker, GSTO1*C, linked to the pre-stage of Alzheimer’s disease

Positive and negative early life experiences differentially modulate long term survival and amyloid protein levels in a mouse model of Alzheimer’s disease

MEF2C rs190982 polymorphism with late-onset Alzheimer’s disease in Han Chinese: A replication study and meta-analyses

Age-related increase of thromboxane B₂ and risk of cardiovascular disease in atrial fibrillation

Transient enhancement of proliferation of neural progenitors and impairment of their long-term survival in p25 transgenic mice

Inhibition of DNA methyltransferase 1 increases nuclear receptor subfamily 4 group A member 1 expression and decreases blood glucose in type 2 diabetes

IL-2 and IL-6 cooperate to enhance the generation of influenza-specific CD8 T cells responding to live influenza virus in aged mice and humans

Clinicopathological and immunohistochemical characterization of papillary proliferation of the endometrium: A single institutional experience

TSH inhibits SERCA2a and the PKA/PLN pathway in rat cardiomyocytes

The comprehensive summary of surgical versus non-surgical treatment for obesity: a systematic review and meta-analysis of randomized controlled trials

The associations between serum biomarkers and stenosis of the coronary arteries

Prognostic relevance of autophagy markers LC3B and p62 in esophageal adenocarcinomas

Dendritic cell-derived VEGF-A plays a role in inflammatory angiogenesis of human secondary lymphoid organs and is driven by the coordinated activation of multiple transcription factors

Toxicological assessment of multi-walled carbon nanotubes in vitro: potential mitochondria effects on male reproductive cells

ATG4A promotes tumor metastasis by inducing the epithelial-mesenchymal transition and stem-like properties in gastric cells

Mutations of KRAS, NRAS, BRAF, EGFR, and PIK3CA genes in urachal carcinoma: Occurence and prognostic significance

Treatment of diabetes mellitus-induced erectile dysfunction using endothelial progenitor cells genetically modified with human telomerase reverse transcriptase

Activation of NLRP3 inflammasomes in mouse hepatic stellate cells during Schistosoma J. infection

Analysis of the correlation between lipotoxicity and pituitary-thyroid axis hormone levels in men and male rats

Activation of volume-sensitive Cl^- channel mediates autophagy-related cell death in myocardial ischaemia/reperfusion injury

Immunoproteomic identification of MbovP579, a promising diagnostic biomarker for serological detection of Mycoplasma bovis infection

Schlafen2 mutation unravels a role for chronic ER stress in the loss of T cell quiescence

Immunoglobulin G promotes skin graft acceptance in an immunologically potent rat model

Lymphatic endothelial cells attenuate inflammation via suppression of dendritic cell maturation

Association of FCGR2A rs1801274 polymorphism with susceptibility to autoimmune diseases: A meta-analysis

Mitochondrial oxidative phosphorylation controls cancer cell’s life and death decisions upon exposure to MAPK inhibitors

Heparanase expression upregulates platelet adhesion activity and thrombogenicity

Paeonol protects endotoxin-induced acute kidney injury: potential mechanism of inhibiting TLR4-NF-κB signal pathway

MicroRNA-26b inhibits tumor metastasis by targeting the KPNA2/c-jun pathway in human gastric cancer

miR-590 promotes cell proliferation and invasion in T-cell acute lymphoblastic leukaemia by inhibiting RB1

Plasma dynamic monitoring of soluble c-Met level for EGFR-TKI treatment in advanced non-small cell lung cancer

Prognostic value of the autophagy markers LC3 and p62/SQSTM1 in early-stage non-small cell lung cancer

Cytoplasmic, full length and novel cleaved variant, TBLR1 reduces apoptosis in prostate cancer under androgen deprivation

Polymorphisms in the CHIT1 gene: Associations with colorectal cancer

The effect of celecoxib on tumor growth in ovarian cancer cells and a genetically engineered mouse model of serous ovarian cancer

Efficacy of the combination of MEK and CDK4/6 inhibitors in vitro and in vivo in KRAS mutant colorectal cancer models

Molecular and proteomic insight into Notch1 characterization in hepatocellular carcinoma

Interference with mutagenic aflatoxin B1-induced checkpoints through antagonistic action of ochratoxin A in intestinal cancer cells: a molecular explanation on potential risk of crosstalk between carcinogens

Small RNAs and the competing endogenous RNA network in high grade serous ovarian cancer tumor spread

Minimal contribution of ERK1/2-MAPK signalling towards the maintenance of oncogenic GNAQ^Q209P-driven uveal melanomas in zebrafish

Programmed death-ligand-1 expression in advanced gastric cancer detected with RNA in situ hybridization and its clinical significance

MiR-193a-5p/ERBB2 act as concurrent chemoradiation therapy response indicator of esophageal squamous cell carcinoma

Pinin associates with prognosis of hepatocellular carcinoma through promoting cell proliferation and suppressing glucose deprivation-induced apoptosis

Autophagic flux is highly active in early mitosis and differentially regulated throughout the cell cycle

Homeobox protein VentX induces p53-independent apoptosis in cancer cells

MEK inhibitor PD0325901 and vitamin C synergistically induce hypomethylation of mouse embryonic stem cells

Down-regulation of microRNA-320 suppresses cardiomyocyte apoptosis and protects against myocardial ischemia and reperfusion injury by targeting IGF-1

The chronological sequence of somatic mutations in early gastric carcinogenesis inferred from multiregion sequencing of gastric adenomas

Tumor-selective replication herpes simplex virus-based technology significantly improves clinical detection and prognostication of viable circulating tumor cells

Targeting PI3Kδ and PI3Kγ signalling disrupts human AML survival and bone marrow stromal cell mediated protection

Inhibition of EHMT2/G9a epigenetically increases the transcription of Beclin-1 via an increase in ROS and activation of NF-κB

Pharmacometabolomics study identifies circulating spermidine and tryptophan as potential biomarkers associated with the complete pathological response to trastuzumab-paclitaxel neoadjuvant therapy in HER-2 positive breast cancer

Efficacy of epidermal growth factor receptor inhibitors in combination with chemotherapy in advanced non-small cell lung cancer: A meta-analysis of randomized controlled trials

ARF1 promotes prostate tumorigenesis via targeting oncogenic MAPK signaling

Tumor-tropic endothelial colony forming cells (ECFCs) loaded with near-infrared sensitive Au nanoparticles: A “cellular stove” approach to the photoablation of melanoma

Inhibition of FGF/FGFR autocrine signaling in mesothelioma with the FGF ligand trap, FP-1039/GSK3052230

FKBP14 overexpression contributes to osteosarcoma carcinogenesis and indicates poor survival outcome

Microsatellite instability derived JAK1 frameshift mutations are associated with tumor immune evasion in endometrioid endometrial cancer

Activated dendritic cells delivered in tissue compatible biomatrices induce in-situ anti-tumor CTL responses leading to tumor regression

MicroRNA-613 inhibits cell growth, migration and invasion of papillary thyroid carcinoma by regulating SphK2

Tumor-infiltrating immune cell subpopulations influence the oncologic outcome after intravesical Bacillus Calmette-Guérin therapy in bladder cancer

Screen-identified selective inhibitor of lysine demethylase 5A blocks cancer cell growth and drug resistance

Prognostic value of preoperative serum lactate dehydrogenase levels for resectable gastric cancer and prognostic nomograms

Expression of the receptor for hyaluronic acid mediated motility (RHAMM) is associated with poor prognosis and metastasis in non-small cell lung carcinoma

SCD1 is associated with tumor promotion, late stage and poor survival in lung adenocarcinoma

Suppression of progranulin expression inhibits bladder cancer growth and sensitizes cancer cells to cisplatin

Identification of FRA-1 as a novel player in pancreatic cancer in cooperation with a MUC1: ERK signaling axis

Differential association for N-acetyltransferase 2 genotype and phenotype with bladder cancer risk in Chinese population

Higher methylation intensity induced by EBV LMP1 via NF-κB/DNMT3b signaling contributes to silencing of PTEN gene

MicroRNA-138 acts as a tumor suppressor in non small cell lung cancer via targeting YAP1

A transferrin-target magnetic/fluorescent dual-mode probe significantly enhances the diagnosis of non-small cell lung cancer

Activin B promotes endometrial cancer cell migration by down-regulating E-cadherin via SMAD-independent MEK-ERK1/2-SNAIL signaling

Everolimus induces Met inactivation by disrupting the FKBP12/Met complex

Predictors of long-term response to abiraterone in patients with metastastic castration-resistant prostate cancer: a retrospective cohort study

Tailored multimodality therapy guided by a two-step decision making process for head-and-neck cancer of unknown primary

Soluble Toll-like receptor 4 is a potential serum biomarker in non-small cell lung cancer

Pre-clinical efficacy and synergistic potential of the MDM2-p53 antagonists, Nutlin-3 and RG7388, as single agents and in combined treatment with cisplatin in ovarian cancer

Variants in human papillomavirus receptor and associated genes are associated with type-specific HPV infection and lesion progression of the cervix

Periostin promotes tumor angiogenesis in pancreatic cancer via Erk/VEGF signaling

Tspan5 is an independent favourable prognostic factor and suppresses tumour growth in gastric cancer

BKCa promotes growth and metastasis of prostate cancer through facilitating the coupling between αvβ3 integrin and FAK

Fibronectin on circulating extracellular vesicles as a liquid biopsy to detect breast cancer

Big data and computational biology strategy for personalized prognosis

Evaluating L1CAM expression in human endometrial cancer using qRT-PCR

Indolin-2-one compounds targeting thioredoxin reductase as potential anticancer drug leads

Rab25 acts as an oncogene in luminal B breast cancer and is causally associated with Snail driven EMT

JARID2 promotes invasion and metastasis of hepatocellular carcinoma by facilitating epithelial-mesenchymal transition through PTEN/AKT signaling

Isoliensinine induces dephosphorylation of NF-kB p65 subunit at Ser536 via a PP2A-dependent mechanism in hepatocellular carcinoma cells: roles of impairing PP2A/I2PP2A interaction

MtDNA depleted PC3 cells exhibit Warburg effect and cancer stem cell features

miRNA-337-3p inhibits gastric cancer progression through repressing myeloid zinc finger 1-facilitated expression of matrix metalloproteinase 14

Targeting FOSB with a cationic antimicrobial peptide, TP4, for treatment of triple-negative breast cancer

Reprofiling using a zebrafish melanoma model reveals drugs cooperating with targeted therapeutics

Cdc6 contributes to cisplatin-resistance by activation of ATR-Chk1 pathway in bladder cancer cells

Upregulation of SIRT6 predicts poor prognosis and promotes metastasis of non-small cell lung cancer via the ERK1/2/MMP9 pathway

Integrin alphavbeta3 enhances β-catenin signaling in acute myeloid leukemia harboring Fms-like tyrosine kinase-3 internal tandem duplication mutations: implications for microenvironment influence on sorafenib sensitivity

Multi-kinase inhibitors interact with sildenafil and ERBB1/2/4 inhibitors to kill tumor cells in vitro and in vivo

Functional and prognostic significance of long non-coding RNA MALAT1 as a metastasis driver in ER negative lymph node negative breast cancer

A novel peptide targeting Clec9a on dendritic cell for cancer immunotherapy

Inverse role of distinct subsets and distribution of macrophage in lung cancer prognosis: a meta-analysis

Transcriptomic and proteomic analysis of mouse radiation-induced acute myeloid leukaemia (AML)

Noninvasive detection of tumor-associated mutations from circulating cell-free DNA in hepatocellular carcinoma patients by targeted deep sequencing

Differences in somatic mutation landscape of hepatocellular carcinoma in Asian American and European American populations

Genetic polymorphisms in TNIP1 increase the risk of gastric carcinoma

TREM-1^low is a novel characteristic for tumor-associated macrophages in lung cancer

A new antiproliferative noscapine analogue: chemical synthesis and biological evaluation

Hypoxia potentiates the cytotoxic effect of piperlongumine in pheochromocytoma models

Mesenchymal stem cell-like properties of CD133+ glioblastoma initiating cells

Phenotypic alteration of CD8⁺ T cells in chronic lymphocytic leukemia is associated with epigenetic reprogramming

Extracellular matrix-specific Caveolin-1 phosphorylation on tyrosine 14 is linked to augmented melanoma metastasis but not tumorigenesis

Interaction of DNA demethylase and histone methyltransferase upregulates Nrf2 in 5-fluorouracil-resistant colon cancer cells

Lactic acidosis switches cancer cells from aerobic glycolysis back to dominant oxidative phosphorylation

Tetraspanin-8 promotes hepatocellular carcinoma metastasis by increasing ADAM12m expression

MicroRNA-375 suppresses human colorectal cancer metastasis by targeting Frizzled 8

microRNA-558 facilitates the expression of hypoxia-inducible factor 2 alpha through binding to 5′-untranslated region in neuroblastoma

Upregulation of glycolysis and oxidative phosphorylation in benzo[β]pyrene and arsenic-induced rat lung epithelial transformed cells

Cellular androgen content influences enzalutamide agonism of F877L mutant androgen receptor

Reduced CD146 expression promotes tumorigenesis and cancer stemness in colorectal cancer through activating Wnt/β-catenin signaling

High temperature requirement A3 (HTRA3) expression predicts postoperative recurrence and survival in patients with non-small-cell lung cancer

Clinicopathological features and prognosis of colonic gastrointestinal stromal tumors: evaluation of a pooled case series

Radiobiological modeling of two stereotactic body radiotherapy schedules in patients with stage I peripheral non-small cell lung cancer

Phase I dose-escalation study of helical intensity-modulated radiotherapy-based stereotactic body radiotherapy for hepatocellular carcinoma

Addressing the elephant in the room, therapeutic resistance in non-small cell lung cancer, with epigenetic therapies

Tall cell variant of papillary thyroid carcinoma: current evidence on clinicopathologic features and molecular biology

Tetrandrine, a Chinese plant-derived alkaloid, is a potential candidate for cancer chemotherapy

Multidisciplinary management of hepatocellular carcinoma with portal vein tumor thrombus – Eastern Hepatobiliary Surgical Hospital consensus statement

Adipogenic miRNA and meta-signature miRNAs involved in human adipocyte differentiation and obesity

The emerging roles and therapeutic potential of cyclin-dependent kinase 11 (CDK11) in human cancer

Neuraminidase-1: A novel therapeutic target in multistage tumorigenesis

Engineered nanoparticles induce cell apoptosis: potential for cancer therapy