Reversing stem cell aging

Catalytically inactive telomerase in oncogenesis

Ubiquitin regulates dissociation of DNA repair factors from chromatin

ATM in senescence

Peptide-siRNA nanotherapeutics in arthritis

Heme oxygenase-1: for better, for worse, in sickness and in health

Genetic heterogeneity in cholangiocarcinoma: a major challenge for targeted therapies

RNA nanoparticle as a vector for targeted siRNA delivery into glioblastoma mouse model

Mitochondrial biogenesis is required for the anchorage-independent survival and propagation of stem-like cancer cells

Inhibition of COP9-signalosome (CSN) deneddylating activity and tumor growth of diffuse large B-cell lymphomas by doxycycline

KLF4-SQSTM1/p62-associated prosurvival autophagy contributes to carfilzomib resistance in multiple myeloma models

Genomic instability and cellular stress in organ biopsies and peripheral blood lymphocytes from patients with colorectal cancer and predisposing pathologies

Prevalence and predictive factors of osteoporosis in systemic sclerosis patients: a case-control study

Zinc finger factor 521 enhances adipogenic differentiation of mouse multipotent cells and human bone marrow mesenchymal stem cells

Human bone marrow niche chemoprotection mediated by cytochrome P450 enzymes

Overexpression of PP2A inhibitor SET oncoprotein is associated with tumor progression and poor prognosis in human non-small cell lung cancer

Cyclin-dependent kinase inhibitor dinaciclib potently synergizes with cisplatin in preclinical models of ovarian cancer

Foretinib inhibits angiogenesis, lymphangiogenesis and tumor growth of pancreatic cancer in vivo by decreasing VEGFR-2/3 and TIE-2 signaling

Targeting Notch1 and proteasome as an effective strategy to suppress T-cell lymphoproliferative neoplasms

Essential role for cyclic-AMP responsive element binding protein 1 (CREB) in the survival of acute lymphoblastic leukemia

RRAD inhibits the Warburg effect through negative regulation of the NF-κB signaling

MicroRNA-451 regulates stemness of side population cells via PI3K/Akt/mTOR signaling pathway in multiple myeloma

PARP inhibitor ABT-888 affects response of MDA-MB-231 cells to doxorubicin treatment, targeting Snail expression

Fibulin-5 inhibits Wnt/β-catenin signaling in lung cancer

MicroRNA-21 plays an oncogenic role by targeting FOXO1 and activating the PI3K/AKT pathway in diffuse large B-cell lymphoma

Thyroid hormone-mediated regulation of lipocalin 2 through the Met/FAK pathway in liver cancer

HER-2 and HER-3 expression in liver metastases of patients with colorectal cancer

Loss of CX3CR1 increases accumulation of inflammatory monocytes and promotes gliomagenesis

Upregulation of spondin-2 predicts poor survival of colorectal carcinoma patients

Small-molecule induction of phospho-eIF4E sumoylation and degradation via targeting its phosphorylated serine 209 residue

Irreversible dual inhibitory mode: the novel Btk inhibitor PLS-123 demonstrates promising anti-tumor activity in human B-cell lymphoma

Silencing of PMEPA1 accelerates the growth of prostate cancer cells through AR, NEDD4 and PTEN

Insulin-like growth factor binding protein-3 inhibits cell adhesion via suppression of integrin β₄ expression

MMP3-mediated tumor progression is controlled transcriptionally by a novel IRF8-MMP3 interaction

Upregulation of miR-572 transcriptionally suppresses SOCS1 and p21 and contributes to human ovarian cancer progression

Elevated MARCKS phosphorylation contributes to unresponsiveness of breast cancer to paclitaxel treatment

Accelerated hepatocellular carcinoma development in CUL4B transgenic mice

MiR-338-3p inhibits epithelial-mesenchymal transition in gastric cancer cells by targeting ZEB2 and MACC1/Met/Akt signaling

Malignant T cells express lymphotoxin α and drive endothelial activation in cutaneous T cell lymphoma

The c-Jun/RHOB/AKT pathway confers resistance of BRAF-mutant melanoma cells to MAPK inhibitors

Consequences of combining siRNA-mediated DNA methyltransferase 1 depletion with 5-aza-2’-deoxycytidine in human leukemic KG1 cells

Selective killing of breast cancer cells expressing activated CD44 using CD44 ligand-coated nanoparticles in vitro and in vivo

A small molecule inhibitor of atypical protein kinase C signaling inhibits pancreatic cancer cell transformed growth and invasion

Tag SNPs in long non-coding RNA H19 contribute to susceptibility to gastric cancer in the Chinese Han population

Axl receptor tyrosine kinase is up-regulated in metformin resistant prostate cancer cells

Inhibition of insulin-like growth factor receptor/AKT/mammalian target of rapamycin axis targets colorectal cancer stem cells by attenuating mevalonate-isoprenoid pathway in vitro and in vivo

Lycorine is a novel inhibitor of the growth and metastasis of hormone-refractory prostate cancer

The intrinsic stiffness of human trabecular meshwork cells increases with senescence

Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes

TR4 nuclear receptor increases prostate cancer invasion via decreasing the miR-373-3p expression to alter TGFβR2/p-Smad3 signals

Inhibition of thioredoxin 1 leads to apoptosis in drug-resistant multiple myeloma

Sensitivity to cdk1-inhibition is modulated by p53 status in preclinical models of embryonal tumors

OVOL guides the epithelial-hybrid-mesenchymal transition

DNA strand breaks induced by nuclear hijacking of neuronal NOS as an anti-cancer effect of 2-methoxyestradiol

Cannabinoid receptor CB1 regulates STAT3 activity and its expression dictates the responsiveness to SR141716 treatment in human glioma patients’ cells

Anti-CSF-1 treatment is effective to prevent carcinoma invasion induced by monocyte-derived cells but scarcely by microglia

Trametinib modulates cancer multidrug resistance by targeting ABCB1 transporter

MYCN amplification confers enhanced folate dependence and methotrexate sensitivity in neuroblastoma

Targeting pancreatitis blocks tumor-initiating stem cells and pancreatic cancer progression

Anchoring of both PKA-RIIα and 14-3-3θ regulates retinoic acid induced 16 mediated phosphorylation of heat shock protein 70

Exploiting the potential of autophagy in cisplatin therapy: A new strategy to overcome resistance

Gap junctions modulate glioma invasion by direct transfer of microRNA

Short-term expansion of breast circulating cancer cells predicts response to anti-cancer therapy

PBK/TOPK enhances aggressive phenotype in prostate cancer via β-catenin-TCF/LEF-mediated matrix metalloproteinases production and invasion

Enolase-1 is a therapeutic target in endometrial carcinoma

Ccdc6 knock-in mice develop thyroid hyperplasia associated to an enhanced CREB1 activity

Comprehensive characterization of chemotherapeutic efficacy on metastases in the established gastric neuroendocrine cancer patient derived xenograft model

Metformin-induced energy deficiency leads to the inhibition of lipogenesis in prostate cancer cells

RAS testing in metastatic colorectal cancer: excellent reproducibility amongst 17 Dutch pathology centers

Clinical evaluation of stereotactic radiation therapy for recurrent or second primary mediastinal lymph node metastases originating from non-small cell lung cancer